The invention relates to sphingoglycolip...
Novel colchicine derivatives possessing ...
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4-Nitrophenyl chloroformate
N-Cbz-Phe-Lys(ε-Alloc)-4-aminobenzyl alcohol
N-Cbz-Phe-Lys(ε-Alloc)-4-aminobenzyl 4-nitrophenyl carbonate
| Conditions | Yield |
|---|---|
|
With
pyridine;
In
tetrahydrofuran;
|
95% |
|
With
pyridine;
In
tetrahydrofuran;
at 0 - 20 ℃;
|
71% |
|
With
pyridine;
In
dichloromethane;
Ambient temperature;
|
N-(benzyloxycarbonyl)-phenylalanine-N-hydroxysuccinimide ester
N-Cbz-Phe-Lys(ε-Alloc)-4-aminobenzyl 4-nitrophenyl carbonate
| Conditions | Yield |
|---|---|
|
Multi-step reaction with 3 steps
1: NaHCO3 / 1,2-dimethoxy-ethane; H2O / Ambient temperature
2: 2-ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline / tetrahydrofuran / Ambient temperature
3: pyridine / CH2Cl2 / Ambient temperature
With
pyridine; sodium hydrogencarbonate; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline;
In
tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water;
|
|
|
Multi-step reaction with 3 steps
1: sodium hydrogencarbonate / 1,2-dimethoxyethane; water
2: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran
3: pyridine / tetrahydrofuran
With
4-methyl-morpholine; pyridine; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
tetrahydrofuran; 1,2-dimethoxyethane; water;
|
|
|
Multi-step reaction with 3 steps
1: sodium hydrogencarbonate / water; 1,2-dimethoxyethane
2: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 4-methyl-morpholine / 4 h / 20 °C / Inert atmosphere; Cooling with ice
3: pyridine / tetrahydrofuran / 0 - 20 °C
With
4-methyl-morpholine; pyridine; sodium hydrogencarbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide;
In
tetrahydrofuran; 1,2-dimethoxyethane; water;
|
4-Nitrophenyl chloroformate
N-Cbz-Phe-Lys(ε-Alloc)-4-aminobenzyl alcohol
N-(benzyloxycarbonyl)-phenylalanine-N-hydroxysuccinimide ester
4-aminobenzenemethanol
C55H60FN5O13
C55H61N5O13
Cbz-L-Phe-L-Lys-OH
(2S,3S,4R)-1-O-(α-D-galactopyranosyl)-4-O-(hexacosanoyl)-2-[N-Cbz-Phe-Lys(ε-Alloc)-((4-aminobenzyloxy)carbonyl)amino]octadecane-1,3,4-triol
