MF： C32H49 N6 O10 P S
Linear and cyclic hexameric peptides wer...
H-L-Tyr-(OPO3Me2)-Val-Pro-Met-Leu-Gly-OH
cyclo
| Conditions | Yield |
|---|---|
|
With
4-methyl-morpholine; ethylenediaminetetraacetic acid; trimethylsilyl bromide; methyl-phenyl-thioether; diphenyl-phosphinic acid; 3-methyl-phenol;
Yield given. Multistep reaction;
1.) DMF, 25 deg C, 48 h, 2.) TFA, 25 deg C, 3 h;
|
Nα-(tert-butoxycarbonyl)-O-(O',O''-dimethylphosphoro)-L-tyrosine
cyclo
| Conditions | Yield |
|---|---|
|
Multi-step reaction with 2 steps
1: 1.) 20percent piperidine, 2.) DIPCDI, HOBt, 3.) TFA / 1.) DMF, 10 min, 2.) DMF, 3.) H2O, 1 h
2: 1.) DPPA, NMM, 2.) 1M TMSBr, thioanisole, m-cresol, EDT / 1.) DMF, 25 deg C, 48 h, 2.) TFA, 25 deg C, 3 h
With
piperidine; 4-methyl-morpholine; ethylenediaminetetraacetic acid; trimethylsilyl bromide; 1,3-di-tert-butylcarbodiimide; methyl-phenyl-thioether; diphenyl-phosphinic acid; benzotriazol-1-ol; 3-methyl-phenol; trifluoroacetic acid;
|
Nα-(tert-butoxycarbonyl)-O-(O',O''-dimethylphosphoro)-L-tyrosine
