MF： C25H48N8O10
|
General Description |
Tuftsin acetate salt is a synthetic derivative of the naturally occurring tetrapeptide tuftsin. It is a white to off-white powder with the chemical formula C22H33N7O7. Tuftsin acetate salt has been studied for its potential immunomodulatory and anti-tumor effects. It has been shown to enhance the activity of immune cells, such as macrophages and natural killer cells, and to increase the production of tumor necrosis factor alpha (TNF-α), which plays a key role in the body's immune response to cancer. Tuftsin acetate salt is currently being investigated for its potential as a therapeutic agent in cancer treatment and other immune-related disorders. |
InChI:InChI=1/C21H40N8O6.C2H4O2/c1-12(30)16(23)18(32)27-13(6-2-3-9-22)19(33)29-11-5-8-15(29)17(31)28-14(20(34)35)7-4-10-26-21(24)25;1-2(3)4/h12-16,30H,2-11,22-23H2,1H3,(H,27,32)(H,28,31)(H,34,35)(H4,24,25,26);1H3,(H,3,4)
A convenient and quick synthesis of tuft...
acetic acid
N-t-butoxycarbonyl-O-benzyl-L-threonyl-Nε-benzyloxycarbonyl-L-lysyl-L-prolyl-Nω-nitro-L-arginine 4-picolyl ester
tuftsin
| Conditions | Yield |
|---|---|
|
With
hydrogen;
palladium on activated charcoal;
In
methanol;
for 12h;
Ambient temperature;
|
53% |
N-benzyloxycarbonyl-L-threonyl-Nε-benzyloxycarbonyl-L-lysyl-L-prolyl-Nω-nitro-L-arginine 4-picolyl ester
trifluoroacetic acid
tuftsin
| Conditions | Yield |
|---|---|
|
With
hydrogen;
palladium on activated charcoal;
Yield given. Multistep reaction;
1) methanol, acetic acid, 16hr, 2) 30 min;
|
acetic acid
N-t-butoxycarbonyl-O-benzyl-L-threonyl-Nε-benzyloxycarbonyl-L-lysyl-L-prolyl-Nω-nitro-L-arginine 4-picolyl ester
N-benzyloxycarbonyl-L-threonyl-Nε-benzyloxycarbonyl-L-lysyl-L-prolyl-Nω-nitro-L-arginine 4-picolyl ester
trifluoroacetic acid
