

A robust dithiocarbamate tether allows n...
Prostate-specific membrane antigen (PSMA...
New DOTA-based bifunctional prochelators...
1-(tert-butyl) 5-methyl 2-(4,7,10-tris(2-(tert-butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecan-1-yl)pentanedioate
(R,S)-5-(tert-butoxy)-5-oxo-4-(4,7,10-tris(2-(tert-butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecan-1-yl)pentanoic acid
| Conditions | Yield |
|---|---|
|
With
sodium hydroxide;
In
methanol;
at 50 ℃;
|
81% |
|
With
sodium hydroxide;
In
methanol;
at 20 ℃;
for 2h;
|
70% |
1-(1-carbobenzyloxy-3-carbotertbutoxypropyl)-4,7,10-(carbotertbutoxymethyl)-1,4,7,10-tetraazacyclododecane
(R,S)-5-(tert-butoxy)-5-oxo-4-(4,7,10-tris(2-(tert-butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecan-1-yl)pentanoic acid
| Conditions | Yield |
|---|---|
|
With
hydrogen;
palladium on activated charcoal;
In
methanol; water;
for 48h;
|
84.6% |
1-(1-carbobenzyloxy-3-carbotertbutoxypropyl)-4,7,10-(carbotertbutoxymethyl)-1,4,7,10-tetraazacyclododecane
bromoacetic acid tert-butyl ester
tert-Butyl 2,2,2-trichloroacetimidate
α-bromoglutaric acid 1-tert-butyl ester 5-benzyl ester
C59H101N11O17S
C43H69N11O17S