• CAS#188968-51-6
  • NameCilengitide
  • For reserach use only and not for human use!

Product Details

MF: C27H40N8O7

Cost-effective and customizable Cilengitide 188968-51-6 factory

  • Molecular Formula:C27H40N8O7
  • Molecular Weight:588.664
  • Refractive Index:1.643 
  • PKA:4.01±0.10(Predicted) 
  • PSA:235.91000 
  • Density:1.41 g/cm3 
  • LogP:0.47830 

2-[(2S,5R,8S,11S)-5-benzyl-11-[3-(diaminomethylideneamino)propyl]-7-methyl-3,6,9,12,15-pentaoxo-8-propan-2-yl-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid(Cas 188968-51-6) Usage

Biochem/physiol Actions

It exhibits antitumor activity in glioblastoma multiforme tumors. Integrins are heterodimers of α and β chain. They are transmembrane receptors which are responsible for cell-to-cell and cell-extracellular matrix interactions. They control tumor angiogenesis, invasion and migration.

InChI:InChI=1/C27H40N8O7/c1-15(2)22-25(41)33-17(10-7-11-30-27(28)29)23(39)31-14-20(36)32-18(13-21(37)38)24(40)34-19(26(42)35(22)3)12-16-8-5-4-6-9-16/h4-6,8-9,15,17-19,22H,7,10-14H2,1-3H3,(H,31,39)(H,32,36)(H,33,41)(H,34,40)(H,37,38)(H4,28,29,30)/t17-,18-,19+,22-/m0/s1

188968-51-6 Relevant articles

Pharmaceutical composition comprising oligopeptides

-

Page/Page column 103-104, (2016/09/26)

The present invention relates to a pharm...

Small Cause, Great Impact: Modification of the Guanidine Group in the RGD Motif Controls Integrin Subtype Selectivity

Kapp, Tobias G.,Fottner, Maximilian,Maltsev, Oleg V.,Kessler, Horst

supporting information, p. 1540 - 1543 (2016/02/14)

Due to its unique role as a hydrogen-bon...

COMPOSITIONS CONTAINING CYCLIC PEPTIDES AND METHODS OF USE

-

Paragraph 0589; 0590, (2015/11/09)

The invention relates generally to cycli...

NOVEL SOLID MATERIALS OF AND METHODS FOR OBTAINING THEM

-

, (2012/03/27)

The instant invention relates to novel s...

188968-51-6 Process route

cilengitide trifluoroacetate
199807-35-7

cilengitide trifluoroacetate

cilengtide
188968-51-6

cilengtide

Conditions
Conditions Yield
In water; vacuum evaporation;
With ammonium hydroxide; In water; at 20 ℃; pH=6.8;
C<sub>27</sub>H<sub>40</sub>N<sub>8</sub>O<sub>7</sub>*ClH
188969-00-8

C27H40N8O7*ClH

cilengtide
188968-51-6

cilengtide

Conditions
Conditions Yield
With ammonium hydroxide; In water; at 4 ℃; pH=6.8;

188968-51-6 Upstream products

  • 199807-35-7
    199807-35-7

    cilengitide trifluoroacetate

  • 188969-00-8
    188969-00-8

    C27H40N8O7*ClH

188968-51-6 Downstream products

  • 199807-38-0
    199807-38-0

    CH4O3S*C27H40N8O7

  • 188969-00-8
    188969-00-8

    C27H40N8O7*ClH

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