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A compound of general formula (I): where...
The present invention relates to combina...
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![tri-tert-butyl (3S,10S,14S)-3-[(naphthalen-2-yl)methyl]-1,4,12-trioxo-1-[(1r,4S)-4-({2-[4,7,10-tris(2-tert-butoxy-2-oxoethyl)-1,4,7,10-tetraazacyclododecan-1-yl]acetamido}methyl)cyclohexyl]-2,5,11,13-tetraazahexadecane-10,14,16-tricarboxylate](/upload/2025/11/9d32fc98-8595-434d-90c1-38892997357d.png)
tri-tert-butyl (3S,10S,14S)-3-[(naphthalen-2-yl)methyl]-1,4,12-trioxo-1-[(1r,4S)-4-({2-[4,7,10-tris(2-tert-butoxy-2-oxoethyl)-1,4,7,10-tetraazacyclododecan-1-yl]acetamido}methyl)cyclohexyl]-2,5,11,13-tetraazahexadecane-10,14,16-tricarboxylate
![(3S,10S,14S)-3-[(naphthalen-2-yl)methyl]-1,4,12-trioxo-1-[(1r,4S)-4-({2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecan-1-yl]acetamido}methyl)cyclohexyl]-2,5,11,13-tetraazahexadecane-10,14,16-tricarboxylic acid](/upload/2025/11/c1e55e27-5cc2-4e3d-80b7-c0ebc0c410a5.png)
(3S,10S,14S)-3-[(naphthalen-2-yl)methyl]-1,4,12-trioxo-1-[(1r,4S)-4-({2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecan-1-yl]acetamido}methyl)cyclohexyl]-2,5,11,13-tetraazahexadecane-10,14,16-tricarboxylic acid
| Conditions | Yield |
|---|---|
|
With
trifluoroacetic acid;
In
dichloromethane;
at 18 - 25 ℃;
Inert atmosphere;
|
64% |
Fmoc-Lys(ivDde)-Wang resin
C14H23NO5
![(1R,4R)-4-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclohexane-1-carboxylic acid](/upload/2025/11/3383703c-eda4-43c4-b210-b31f4696a3d8.png)
(1R,4R)-4-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclohexane-1-carboxylic acid
1,4,7-tris(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane-10-acetic acid
PMSA-617
| Conditions | Yield |
|---|---|
|
Fmoc-Lys(ivDde)-Wang resin; C14H23NO5;
With
hydrazine;
In
N,N-dimethyl-formamide;
Wang resin
(1r,4r)-4-(((((9H-fluoren-9-yl)methoxy)carbonyl)amino)methyl)cyclohexane-1-carboxylic acid; 1,4,7-tris(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane-10-acetic acid;
In
N,N-dimethyl-formamide;
Wang resin
With
trifluoroacetic acid;
In
N,N-dimethyl-formamide;
|
25% |
1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid mono(N-hydroxysuccinimidyl ester)
(1R,4R)-4-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclohexane-1-carboxylic acid
1,4,7-tris(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane-10-acetic acid
N-(9-fluorenylmethoxycarbonyl)-3-(β-naphthyl)-L-alanine
